FDA Approves Wyeth Pharms's Torisel
Torisel is a cancer medication. It slows the growth and spread of cancer cells in the body. Torisel is used to treat cancer of the kidneys, also called renal cell carcinoma.
Torisel is a derivative of rapamycin, an agent that exhibits antifungal, immunosuppressant and antitumor activities. Torisel appears to block the effects of mTOR, an enzyme that has an important role in regulating the synthesis of proteins that control cell division. Therefore, Torisel may stop the production of proteins essential for cancer cell proliferation.
Torisel is specifically indicated for the treatment of advanced renal cell carcinoma.
Torisel is supplied as a 25 mg/mL injection with a 1.8 mL diluent designed for injection. The recommended initial dose of the drug is 25 mg infused over a 30-60 minute period once a week. Treat until disease progression or unacceptable toxicity.Torisel injection vial contents must first be diluted with the enclosed diluent before diluting the resultant solution with 250 mL of 0.9% sodium chloride injection.
TORISEL is a treatment for advanced renal cell carcinoma (RCC).
TORISEL is the first and only mammalian target of rapamycin (mTOR) inhibitor for the treatment of advanced RCC.
mTOR is a protein found inside the body’s cells that plays a role in cell growth and division.
By inhibiting mTOR, TORISEL blocks the processes through which both normal cells and cancerous kidney cells grow and divide.
TORISEL may help stop the creation of new blood vessels that feed the advanced RCC cells.
Torisel™ is a kinase inhibitor used to treat advanced kidney cancer, also known as advanced renal cell carcinoma.
Torisel™ is what is known as an mTOR inhibitor that is administered intravenously once a week. mTOR stands for "mammalian target of rapamycin." A protein plays a very important role in controlling the natural life cycle of cells in the kidneys (renal cells). In patients with kidney cancer, changes have been incurred in cell function that creates an accelerated growth rate of cells to form tumors. As an mTOR inhibitor, Torisel™ may interfere with the cell growth process to decrease tumor cell growth rates.