FDA Approves IPR's Crestor

Crestor is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Crestor is used to lower cholesterol and triglycerides (types of fat) in the blood.

Crestor is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors

Crestor is used in adults and children who are at least 10 years old.

Most of the cholesterol in our blood is made within our bodies, by the liver. And that's where CRESTOR® (rosuvastatin calcium) comes in. CRESTOR works by blocking an enzyme in the liver. It helps to lower LDL (bad) cholesterol produced by the liver and raises HDL (good) cholesterol. Along with diet, CRESTOR can also slow the progression of atherosclerosis, the progressive buildup of plaque in the arteries over time, as part of a treatment plan in adults to lower cholesterol to goal.

By limiting cholesterol production, CRESTOR lowers the amount of total cholesterol that ends up in the bloodstream. CRESTOR can lower LDL cholesterol up to 52% (at the 10-mg dose versus 7% with placebo). It can also raise the amount of HDL cholesterol in the blood by up to 14% (at the 10-mg dose versus 3% with placebo). Of course, your results may vary.

As with any medicine, there are possible side effects with Crestor® (rosuvastatin calcium). However, not everyone who takes this medicine will have problems. In fact, most people tolerate it well. When side effects do occur, in most cases they are minor and either require no treatment or can easily be treated by you or your healthcare provider. In previous research studies, up to 5.6 percent of people taking Crestor stopped their prescription because of side effects.

Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver.

Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood. It is indicated for primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Type IIa and IIb).

It is also indicated as an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV) and in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments.

The dose range for Crestor is 5 to 40 mg once daily. Therapy should be individualized according to goal of therapy and response.