South Park Episode 506 - "Cartmanland"

Cartman inherits ONE MILLION DOLLARS from his grandmother, fulfilling his lifelong dream of owning his own amusement park, Cartmanland!

A hemorrhoid erupts in Kyle's ass when he learns of Cartman's undeserved fortune, making him question the very existence of God, and whether there's a reason to stay alive in a world where someone like Cartman is happy.