FDA Approves ViiV Healthcare's Trizivir

Trizivir is an antiviral medication.

It is in a group of human immunodeficiency virus (HIV) medicines called reverse transcriptase inhibitors. This medication helps keep the HIV virus from reproducing in the body.

Trizivir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). It is not a cure for HIV or AIDS.

Trizivir may also be used for other purposes not listed in this medication guide. Trizivir should not be given to people who weigh less than 90 pounds.

Trizivir is an HIV medication. It is in a category of HIV medicines called nucleoside reverse transcriptase inhibitors (NRTIs). Trizivir prevents HIV from entering the nucleus of healthy CD4 cells. This prevents the cells from producing new virus and decreases the amount of virus in the body.

Trizivir is marketed by ViiV Healthcare. It was approved by the U.S. Food and Drug Administration (FDA) for use by people living with HIV in 2000.

Trizivir is a combination of three previously approved drugs: 300mg of Retrovir (zidovudine), 150mg of Epivir (lamivudine), and 300mg of Ziagen (abacavir). Trizivir should be prescribed by a healthcare provider for patients who need to take all three drugs. For patients only taking zidovudine and lamivudine, a combination tablet called Combivir is available. For patients only taking abacavir and lamivudine, a combination tablet called Epzicom is available. Also, any of these three drugs can be purchased individually for use in combination with other HIV drugs.

Trizivir is a pill that contains three antiretroviral drugs (ARVs) used to fight HIV: zidovudine (Retrovir, AZT), lamivudine (Epivir, 3TC), and (abacavir (Ziagen). Trizivir is manufactured by ViiV Healthcare. Generic versions have been tentatively approved under PEPFAR (see fact sheet 475.)

The drugs in Trizivir are called nucleoside analog reverse transcriptase inhibitors, or nukes. These drugs block the reverse transcriptase enzyme. This enzyme changes HIV’s genetic material (RNA) into the form of DNA. This has to occur before HIV’s genetic code gets inserted into an infected cell’s own genetic codes.

Trizivir tablets contain three nucleoside analogues; abacavir sulfate (Ziagen), lamivudine (Epivir or 3TC) and zidovudine (Retrovir, ZDV or azidothymidine). This combination therapy has been developed to simplify the dosing regimen for HIV patients. It is available by prescription only and is not indicated for pediatric patients. Severe hypersensitivity warnings have been posted. Please note these warnings and notify a physician immediately if signs occur.