South Park Episode 316 - "Are You There God? It's Me, Jesus"

Cartman is convinced he is going through puberty since he started bleeding out of his ass.

Dr. Mephisto gives Stan some hormones and he takes the entire bottle. Stan gets facial hair, boobs and his voice starts changing. People are waiting outside of Jesus' home to see what kind of miracle he offers which ends up involving a comeback performance of a very old Rod Stewart and eventually an appearance by God.