FDA Approves Stiefel's Soriatane

Treating severe psoriasis. Soriatane is a kit that contains a vitamin A derivative (retinoid) and moisturizing foam. Exactly how the retinoid works is not known. The moisturizing foam relieves dry and chapped skin.

Acitretin is an oral retinoid, which is a synthetic form of vitamin A. Soriatane is the only oral retinoid approved by the FDA specifically for treating psoriasis.

The exact way acitretin works to control psoriasis is unknown. In general, retinoids help control the multiplication of cells including the speed at which skin cells grow and shed.

Do not take Soriatane if:

You are pregnant, planning to become pregnant, or breastfeeding:
You have severe liver or kidney disease:
You have high triglycerides;
You are allergic to retinoids.

Acitretin (trade name Soriatane) is a second generation retinoid. It is taken orally, and is typically used for psoriasis.
It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant.
Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.

Soriatane (acitretin) is an oral medication which is used to treat Psoriasis. It is the first treatment which is beneficial for all 5 types of Psoriasis namely plaque, guttate, erythrodermic, pustular, and palmar-plantar.

How Soriatane works?

Soriatane classified as being related to retinoid (Vitamin A). It basically works inhibiting certain receptors, thereby aiding in enhancing the growth of skin cells. This activity in turn facilitates the fading away of skin associated diseases such as Psoriasis.