FDA Approves Novartis's Lotrel to Lower Hypertension

Lotrel is a combination medication that contains an angiotensin converting enzyme (ACE) inhibitor and a calcium-channel blocker.

It is used in the treatment of high blood pressure. High blood pressure is an asymptomatic condition in which the blood flowing through the body places an excessive load on the arterial walls. Patients with high blood pressure are at higher risk of experiencing adverse events such as heart attack and stroke. Lotrel helps reduce blood pressure by relaxing the blood vessels.

Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5-10 mg and benazepril doses of 10-40 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups.

The antihypertensive effect of Lotrel is largely attained within 2 weeks.

It is usually appropriate to begin therapy with Lotrel only after a patient has either (a) failed to achieve the desired antihypertensive effect with one or the other monotherapy, or (b) demonstrated inability to achieve adequate antihypertensive effect with amlodipine therapy without developing edema.

Lotrel is used in the treatment of high blood pressure. It is a combination medicine that is used when treatment with a single drug has not been successful or has caused side effects.

One component, amlodipine, is a calcium channel blocker. It eases the workload of the heart by slowing down the passage of nerve impulses and hence the contractions of the heart muscle. This improves blood flow through the heart and throughout the body and reduces blood pressure. The other component, benazepril, is an angiotensin-converting enzyme (ACE) inhibitor. It works by preventing the transformation of a hormone called angiotensin I into a more potent substance that increases salt and water retention in your body.