Physician William Schwartz Administers Sulfanilamide to Help with Hypertension

In 1949, Bill Schwartz reported that three patients with marked edema due to heart failure who were given sulfonamides all showed dramatic improvement but that these drugs were also "too toxic for prolonged or routine use."

In 1949, Boston physician William Schwartz administered large doses of sulfanilamide by mouth to obtain a diuretic effect in three patients with congestive heart failure but he had to abandon this approach because of toxic side effects.