Toremifene, also known as Fareston, is a synthetic compound similar to estrogen. It mimics the action of estrogen on the bones and uterus, but blocks the effects of estrogen on breast tissue.
Toremifene is used as adjuvant hormone therapy immediately after surgery in early stages of breast cancer and also to treat advanced metastatic breast cancer (stages III and above) in postmenopausal women. Postmenopausal women at high risk of developing breast cancer may take toremifene to reduce risk.
Toremifene is similar to tamoxifen in structure and action. Toremifene can be given as sole treatment, but it is often given in combination with other chemotherapeutic drugs.
Toremifene belongs to a family of compounds called antiestrogens. Antiestrogens are used in cancer therapy by inhibiting the effects of estrogen on target tissues. Estrogen is a steroid hormone secreted by granulosa cells of a maturing follicle within the female ovary.