Cozaar (losartan potassium tablets), a once-daily prescription medication that represents the first new class of medicines for the treatment of high blood pressure in more than a decade, has been cleared for marketing by the U.S. Food and Drug Administration, Merck & Co. Inc., announced Tuesday.
Cozaar is the first in a new class of effective antihypertensive drugs called Angiotensin-II (A-II) receptor blockers. Cozaar lowers high blood pressure by blocking A-II. A hormone, A-II causes narrowing of the blood vessels and salt and water retention by the kidneys. Cozaar blocks A-II, which resulted in gradual, smooth, 24-hour blood pressure reduction in clinical studies, with a low incidence of side effects.