In March 1945, a typhus epidemic spread through the camp and killed approximately 17,000 prisoners. Witnesses later testified that Margot fell from her bunk in her weakened state and was killed by the shock, and that a few days later Anne died. They stated that this occurred a few weeks before the camp was liberated by British troops on 15 April 1945, although the exact dates were not recorded. After liberation, the camp was burned in an effort to prevent further spread of disease, and Anne and Margot were buried in a mass grave, the exact whereabouts of which is unknown.
After the war, it was estimated that of the 107,000 Jews deported from the Netherlands between 1942 and 1944, only 5,000 survived. It was also estimated that up to 30,000 Jews remained in the Netherlands, with many people aided by the Dutch underground. Approximately two-thirds of these people survived the war.
Otto Frank survived his internment in Auschwitz. After the war ended, he returned to Amsterdam where he was sheltered by Jan and Miep Gies, as he attempted to locate his family. He learned of the death of his wife, Edith, in Auschwitz, but he remained hopeful that his daughters had survived. After several weeks, he discovered that Margot and Anne also had died. He attempted to determine the fates of his daughters' friends, and learned that many had been murdered. Susanne Ledermann, often mentioned in Anne's diary, had been gassed along with her parents, though her sister, Barbara, a close friend of Margot, had survived. Several of the Frank sisters' school friends had survived, as had the extended families of both Otto and Edith Frank, as they had fled Germany during the mid 1930s, with individual family members settling in Switzerland, the United Kingdom and the United States.