Gayetty's paper, first introduced in 1857, was available as late as the 1920's. Gayetty's Medicated Paper was sold in packages of flat sheets, somewhat like Kleenex boxes. Original advertisements for the product used the tagline "The greatest necessity of the age! Gayetty's medicated paper for the water-closet."
Seth Wheeler of Albany, New York, obtained the earliest patents for toilet paper and dispensers, the types of which eventually were in common usage in the US.
Gayetty first marketed toilet paper in 1857 which originally sold for $0.50 U.S. Dollars in packs of 500 bearing a watermark of his name. The original product contained aloe as a lubricant and was marketed as an anti-hemorrhoid medical product. Gayetty's product was licensed to other manufacturers and sold as late as the 1920's.