Sometime between 1303 and 1310 Giotto executed (and signed) his most influential work, the painted decoration of the interior of the Scrovegni Chapel in Padua. This chapel, the building and decoration of which were commissioned by Enrico degli Scrovegni to atone for the sins of his father, is externally a very plain building of pink brick which was constructed next to an older palace that Scrovegni was restoring for himself. The palace, now gone, and the chapel were on the site of a Roman arena, for which reason it is commonly known as the Arena Chapel.
The theme is Salvation, and there is an emphasis on the Virgin Mary, as the chapel is dedicated to the Annunciation. As is common in the decoration of the Medieval period, the west wall is dominated by the Last Judgement. On either side of the chancel are complementary paintings of the Angel Gabriel and the Virgin Mary, depicting the Annunciation. This scene is incorporated into the cycles of The Life of the Blessed Virgin Mary and The Life of Christ. The source for The Life of the Virgin is the "Golden Legend" of Jacopo da Varazze while The Life of Christ draws upon "Meditations on the Life of Jesus" by the Pseudo-Bonaventura.