Andrew and his troops embarked on 23 August 1217, in Spalato. They landed on 9 October on Cyprus from where they sailed to Acre and joined John of Brienne, ruler of the Kingdom of Jerusalem, Hugh I of Cyprus, and Prince Bohemund IV of Antioch to fight against the Ayyubids in Syria.
In Jerusalem, the walls and fortifications were demolished to prevent the Christians from being able to defend the city, if they did manage reach it and take it. Muslims fled the city, afraid that there would be a repeat of the bloodbath of the First Crusade in 1099.
Andrew's well-mounted army defeated sultan Al-Adil I at Bethsaida on the Jordan River on November 10. Muslim forces retreated in their fortresses and towns. The catapults and trebuchets didn't arrive in time, so he had fruitless assaults on the fortresses of the Lebanon and on Mount Tabor. Afterwards, Andrew spent his time collecting alleged relics.
Andrew and his army departed to Hungary in February 1218, and Bohemund and Hugh also returned home.